Refyne is considered a “next-generation” fillers because it allows for movement within the face with most facial expressions. Studies suggest a more natural expression and appearance vs. the stiffness of traditional fillers.
Restylane Refyne® is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.
According to the manufacturer, Restylane Refyne and Restylane Defyne are the only fillers on the market that have been shown in clinical trials to help maintain natural movement and expressions.-- January, 2017